Kinoshita Hidenori, Shinokubo Hiroshi, Oshima Koichiro
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.
J Am Chem Soc. 2003 Jul 2;125(26):7784-5. doi: 10.1021/ja035438o.
Macrocyclization via rhodium-catalyzed intramolecular [2 + 2 + 2] annulation of triynes has been explored in an aqueous-organic biphasic system. The biphasic system controls the concentration of hydrophobic substrates in the aqueous reaction phase and offers diluted reaction conditions without the use of a slow addition technique. The system also achieves selective cross-annulation between hydrophobic diynes and hydrophilic alkynes.
通过铑催化的三炔分子内[2 + 2 + 2]环化反应进行大环化已在水-有机双相体系中得到探索。该双相体系控制水相反应中疏水性底物的浓度，并提供稀释的反应条件，而无需使用缓慢添加技术。该体系还实现了疏水性二炔和亲水性炔之间的选择性交叉环化。
