铑催化苯酚连接的1,6-二炔通过[2 + 2 + 2]环加成反应灵活合成稠合苯并呋喃衍生物。
Flexible synthesis of fused benzofuran derivatives by rhodium-catalyzed [2 + 2 + 2] cycloaddition with phenol-linked 1,6-diynes.
作者信息
Komine Yoshiyuki, Kamisawa Akiyoshi, Tanaka Ken
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
出版信息
Org Lett. 2009 Jun 4;11(11):2361-4. doi: 10.1021/ol900802d.
PMID:19473045
Abstract
A flexible and convenient synthesis of fused benzofuran derivatives has been achieved under mild reaction conditions by cationic rhodium(I)/H(8)-BINAP complex-catalyzed [2 + 2 + 2] cycloadditions of phenol-linked 1,6-diynes with alkynes and nitriles.
摘要
通过阳离子铑（I）/H（8）-BINAP络合物催化苯酚连接的1,6-二炔与炔烃和腈的[2 + 2 + 2]环加成反应，在温和的反应条件下实现了稠合苯并呋喃衍生物的灵活便捷合成。
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