Misseri Yolande, Labesse Gilles, Bucheton Alain, Terzian Christophe
Institut de Génétique Humaine, 141 rue de la cardonille, F-34396 Montpellier Cedex 5, France.
Trends Microbiol. 2003 Jun;11(6):253-6. doi: 10.1016/s0966-842x(03)00119-7.
Insect endogenous retroviruses (IERVs) are present in the genome of several species. Previous studies have shown a relationship between the envelope glycoproteins (Envs) and fusion proteins (FPs) of several baculoviruses. We used this sequence similarity to predict fusion domains in the Envs of IERVs. We suggest that FPs and Envs share several specific sequence and structural motifs with other RNA viruses in the viral transmembrane protein superfamily.
昆虫内源性逆转录病毒（IERVs）存在于多个物种的基因组中。先前的研究表明，几种杆状病毒的包膜糖蛋白（Envs）与融合蛋白（FPs）之间存在关联。我们利用这种序列相似性来预测IERVs包膜糖蛋白中的融合结构域。我们认为，在病毒跨膜蛋白超家族中，融合蛋白和包膜糖蛋白与其他RNA病毒共享一些特定的序列和结构基序。
