Johansson Jörgen, Cossart Pascale
Unite des Interactions Bacteries-Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Trends Microbiol. 2003 Jun;11(6):280-5. doi: 10.1016/s0966-842x(03)00118-5.
Until recently, gene expression was thought to be controlled mainly at the level of transcription initiation by repressor or activator proteins. In some cases, transcription elongation is controlled by a so-called attenuation mechanism that involves alternative base-pairing between different regions of an mRNA transcript. Recent data reveal that other mechanisms can regulate gene expression and involve RNAs that might act as antisense RNAs, sequestering molecules, or thermosensors. This review focuses on recent studies in bacterial pathogens in which a growing list of examples show that RNA can control virulence gene expression.
直到最近，人们还认为基因表达主要在转录起始水平受到阻遏蛋白或激活蛋白的控制。在某些情况下，转录延伸由一种所谓的衰减机制控制，该机制涉及mRNA转录本不同区域之间的交替碱基配对。最近的数据表明，其他机制也可以调节基因表达，这些机制涉及可能充当反义RNA、隔离分子或热传感器的RNA。本综述重点关注细菌病原体的最新研究，越来越多的例子表明RNA可以控制毒力基因的表达。
