Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, 90187 Umeå, Sweden.
Nat Rev Microbiol. 2010 Dec;8(12):857-66. doi: 10.1038/nrmicro2457.
RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.
调控蛋白质表达的 RNA 途径比人们之前认为的要广泛得多。调控 RNA，包括编码序列附近的 5' 和 3' 非翻译区、顺式作用反义 RNA 和反式作用小非编码 RNA，是有效的调控分子，可以响应外部信号（如温度、pH 值和代谢物水平）影响蛋白质的表达和功能。这篇综述讨论了这些调控 RNA 与 RNase 等辅助蛋白一起控制 mRNA 和蛋白质命运的机制，以及这种调控如何影响致病菌的毒力。
