Hoebertz Astrid, Arnett Timothy R, Burnstock Geoffrey
Research Institute of Molecular Biology, Dr Bohr Gasse 7, 1030 Vienna, Austria.
Trends Pharmacol Sci. 2003 Jun;24(6):290-7. doi: 10.1016/S0165-6147(03)00123-8.
Growing evidence suggests that extracellular nucleotides, signalling through P2 receptors, might play important roles in the regulation of bone and cartilage metabolism. ATP and other nucleotides can exert impressive stimulatory effects on the formation and activity of osteoclasts (bone-resorbing cells) in addition to inhibiting bone formation by osteoblasts. In this review, the current understanding of the actions of nucleotides on skeletal cells and the probable receptor subtypes involved are discussed.
越来越多的证据表明，通过P2受体发出信号的细胞外核苷酸可能在骨骼和软骨代谢的调节中发挥重要作用。除了抑制成骨细胞的骨形成外，三磷酸腺苷（ATP）和其他核苷酸还可对破骨细胞（骨吸收细胞）的形成和活性产生显著的刺激作用。在这篇综述中，我们讨论了目前对核苷酸作用于骨骼细胞的理解以及可能涉及的受体亚型。
