Song Shuaiwei, Cai Xintian, Hu Junli, Zhu Qing, Shen Di, Ma Huimin, Zhang Yingying, Ma Rui, Zhou Pan, Yang Wenbo, Hong Jing, Li Nanfang
Hypertension Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China.
Xinjiang Hypertension Institute, Urumqi 830001, China.
Metabolites. 2025 Jan 3;15(1):15. doi: 10.3390/metabo15010015.
The influence of serum uric acid (SUA) on bone metabolism, as suggested by previous studies, remains a contentious issue. SUA plays a complex role in bone health and hypertension, making it challenging to discern its impact on the skeletal status of middle-aged and elderly hypertensive patients. This study aims to elucidate the effects of SUA on bone health, with a particular focus on its association with osteoporosis and the risk of fractures.
Multiple linear regression analyzed SUA levels against bone mineral density (BMD) and future fracture risk. Additionally, multivariate logistic regression was used to examine the association between SUA and osteoporosis. Dose-response relationship analysis was conducted using generalized smooth curve fitting (GSCF) and restricted cubic spline (RCS) methods.
With the exception of the total femur region, SUA and BMD showed a positive connection. GSCF analysis revealed an inverted U-shaped relationship between SUA and BMD, alongside a U-shaped trend with FRAX scores. Moreover, RCS analysis indicated a U-shaped relationship between osteoporosis risk and SUA levels, with higher risks identified in the first and third tertiles compared to the second tertile.
In individuals with middle-aged and older hypertension, SUA is substantially linked to bone health. The identification of an inverted U-shaped relationship with BMD and U-shaped relationships with FRAX scores and osteoporosis risk highlights the nuanced influence of SUA. These findings suggest that both low and high SUA levels may adversely affect bone health, emphasizing the need for further research.
既往研究表明，血清尿酸（SUA）对骨代谢的影响仍是一个有争议的问题。SUA在骨骼健康和高血压中发挥着复杂的作用，这使得难以辨别其对中老年高血压患者骨骼状况的影响。本研究旨在阐明SUA对骨骼健康的影响，特别关注其与骨质疏松症及骨折风险的关联。
采用多元线性回归分析SUA水平与骨密度（BMD）及未来骨折风险的关系。此外，使用多因素逻辑回归分析SUA与骨质疏松症之间的关联。采用广义平滑曲线拟合（GSCF）和限制性立方样条（RCS）方法进行剂量反应关系分析。
除全股骨区域外，SUA与BMD呈正相关。GSCF分析显示SUA与BMD之间呈倒U形关系，与FRAX评分呈U形趋势。此外，RCS分析表明骨质疏松症风险与SUA水平呈U形关系，与第二三分位数相比，第一和第三三分位数的风险更高。
在中老年高血压患者中，SUA与骨骼健康密切相关。SUA与BMD呈倒U形关系，与FRAX评分及骨质疏松症风险呈U形关系，这突出了SUA的细微影响。这些发现表明，低水平和高水平的SUA都可能对骨骼健康产生不利影响，强调需要进一步研究。
