Lim Nathaniel C, Yao Lili, Freake Hedley C, Brückner Christian
University of Connecticut, Department of Chemistry, 06269-3060, Storrs, CT, USA.
Bioorg Med Chem Lett. 2003 Jul 21;13(14):2251-4. doi: 10.1016/s0960-894x(03)00464-5.
The synthesis of a coumarin-cyclen conjugate-based zinc-specific chemosensor and its ability to sense Zn(2+) in vitro is described. Using fluorescence microscopy, the chemosensor was shown to be capable of imaging Zn(2+) in live rat pituitary tumour cells.
描述了一种基于香豆素-环烯共轭物的锌特异性化学传感器的合成及其体外检测Zn(2+)的能力。使用荧光显微镜，该化学传感器能够对活的大鼠垂体肿瘤细胞中的Zn(2+)进行成像。
