一种用于在中性pH值的水溶液中检测锌离子（Zn(II)）的“开启型”荧光化学传感器及其在活细胞成像中的应用。
A "turn-on" fluorescent chemosensor for the detection of Zn(II) in aqueous solution at neutral pH and its application in live cells imaging.
作者信息
Li Yuanyuan, Li Kai, He Juan
机构信息
School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, PR China.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, PR China.
出版信息
Talanta. 2016 Jun 1;153:381-5. doi: 10.1016/j.talanta.2016.03.040. Epub 2016 Mar 13.
Pyridoxal-2-hydrazinopyridine Schiff-base (1) was prepared by one-step synthesis from commercially available materials of pyridoxal and 2-hydrazinopyridine. Compound 1 could be applied as a fluorescent chemosensor for Zn(II) in aqueous solution at pH 7.4. After binding to Zn(II) with a molar ratio of 1:1, 1 exhibited 17-fold fluorescence enhancement. In addition, 1 showed a good selectivity toward Zn(II) over other metal ions, which can especially distinguish Zn(II) from Cd(II). A linear range of 5.0-20.0μmolL(-1) and a detection limit of 70nmolL(-1) were also achieved. Moreover, the utility of chemosensor 1 in bioimaging of Zn(II) in living cells was demonstrated, which suggested that 1 could be used as a Zn(II)-selective chemosensor in biological samples.
吡哆醛-2-肼基吡啶席夫碱（1）由市售的吡哆醛和2-肼基吡啶通过一步合成法制备。化合物1可作为pH 7.4水溶液中锌（II）的荧光化学传感器。与锌（II）以1:1的摩尔比结合后，1表现出17倍的荧光增强。此外，1对锌（II）表现出优于其他金属离子的良好选择性，尤其能将锌（II）与镉（II）区分开来。还实现了5.0 - 20.0μmolL⁻¹的线性范围和70nmolL⁻¹的检测限。此外，还证明了化学传感器1在活细胞中锌（II）生物成像中的应用，这表明1可作为生物样品中锌（II）的选择性化学传感器。
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