Chisholm E M, Williams S R, Leung J W, Chung S C, Van Hasselt C A, Li A K
Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Eur J Surg Oncol. 1992 Dec;18(6):550-2.
Lugol's iodine dye indicates the presence of unsuspected early oesophageal cancers during endoscopy at which such cancers fail to show the characteristic black colour change. We evaluated Lugol's iodine dye-enhanced endoscopy in 17 patients with oesophageal cancer. In a further 37 patients with head and neck cancer we examined the use of Lugol's iodine since these patients have a 29% risk of synchronous oesophageal cancer. The oesophagus was sprayed with Lugol's iodine (1.5%) during endoscopy. Any areas not turning black were biopsied. In 13 patients with oesophageal cancer discrete areas beyond the macroscopically obvious primary tumour showed no change in colour. Biopsy revealed cancer in all cases. Six synchronous cancers were found in the head and neck group, one of which was identified only by the use of Lugol's iodine. Lugol's iodine augmented the information gained about the oesophageal mucosa during endoscopy. It revealed unsuspected cancer which altered the management of patients with primary oesophageal cancer as well as those with head and neck cancer. We recommend the routine use of Lugol's iodine-enhanced endoscopy for surveillance of all 'at risk' oesophageal cases.
卢戈氏碘液染色可在内镜检查时发现未被怀疑的早期食管癌，此类癌症在检查时不会出现特征性的黑色变色。我们对17例食管癌患者进行了卢戈氏碘液染色增强内镜检查。另外，对37例头颈癌患者也进行了卢戈氏碘液检查，因为这些患者患同步性食管癌的风险为29%。在内镜检查期间，向食管喷洒卢戈氏碘液（1.5%）。对任何未变黑的区域进行活检。在13例食管癌患者中，肉眼可见的原发肿瘤以外的离散区域未出现颜色变化。活检在所有病例中均发现癌症。在头颈癌组中发现了6例同步性癌症，其中1例仅通过使用卢戈氏碘液得以确诊。卢戈氏碘液增加了内镜检查期间获得的有关食管黏膜的信息。它揭示了未被怀疑的癌症，这改变了原发性食管癌患者以及头颈癌患者的治疗方案。我们建议对所有“高危”食管病例进行常规的卢戈氏碘液染色增强内镜检查以进行监测。
