Nagahama Yasuhiro, Nabatame Hidehiko, Okina Tomoko, Yamauchi Hiroshi, Narita Minoru, Fujimoto Naoki, Murakami Motonobu, Fukuyama Hidenao, Matsuda Minoru
Department of Geriatric Neurology, Shiga Medical Center, Moriyama, Japan.
Eur Neurol. 2003;50(1):1-9. doi: 10.1159/000070851.
To evaluate the possible relation between the rate of cognitive deterioration in patients with probable Alzheimer's disease (AD) and the distribution pattern of neural dysfunction.
The regional cerebral blood flow (rCBF) was measured in rapidly and slowly progressing groups of AD patients using single-photon emission computed tomography and was compared between the groups. While controlling for demographic and clinical factors that could be associated with the stage and prognosis of the illness, the deterioration rate of the Mini Mental State Examination (MMSE) score was significantly greater in the rapidly progressing group than that in the slowly progressing group.
The rCBF in the right posterodorsal, anterior and superior prefrontal cortices and the inferior parietal cortex was significantly lower in the rapidly progressing patients. Moreover, lower perfusion in these regions correlated significantly with rapid deterioration in the MMSE.
These findings suggest that the rCBF values in these cortical regions could be useful in predicting which AD patients will show a relatively rapid cognitive decline.
评估可能患阿尔茨海默病（AD）患者的认知衰退速率与神经功能障碍分布模式之间的潜在关系。
使用单光子发射计算机断层扫描对快速进展型和缓慢进展型AD患者组进行局部脑血流（rCBF）测量，并在两组之间进行比较。在控制可能与疾病阶段和预后相关的人口统计学和临床因素的同时，快速进展组的简易精神状态检查表（MMSE）评分的衰退速率显著高于缓慢进展组。
快速进展型患者右侧后背部、前额叶前部和上部以及顶下皮质的rCBF显著降低。此外，这些区域的灌注降低与MMSE的快速衰退显著相关。
这些发现表明，这些皮质区域的rCBF值可能有助于预测哪些AD患者会出现相对快速的认知衰退。
