Haverkamp Margje, Smit Maarten, Weersink Annemarie, Boucher Charles A, Hoepelman Andy I
Department of Medicine, Division of Acute Medicine and Infectious Diseases, Utrecht, The Netherlands.
AIDS. 2003 Jul 4;17(10):1572-4. doi: 10.1097/00002030-200307040-00023.
We retrospectively analysed the effect of lamivudine on hepatitis B virus (HBV) in HIV-co-infected patients. In this small study we document a CD4 cell-dependent response on HBV replication with lamivudine therapy. In this respect, hepatitis B may be considered an opportunistic infection. Our finding may have important clinical consequences, and large prospective studies are necessary to investigate this further.
我们回顾性分析了拉米夫定对合并感染人类免疫缺陷病毒（HIV）患者的乙型肝炎病毒（HBV）的影响。在这项小型研究中，我们记录了拉米夫定治疗对HBV复制的CD4细胞依赖性反应。在这方面，乙型肝炎可被视为一种机会性感染。我们的发现可能具有重要的临床意义，有必要开展大型前瞻性研究作进一步调查。
