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一名肝硬化和慢性肾衰竭患者的鼻脑毛霉菌病

Rhinocerebral mucormycosis in a patient with cirrhosis and chronic renal failure.

作者信息

Georgopoulou Stavroula, Kounougeri Ekaterini, Katsenos Chrisostomos, Rizos Michael, Michalopoulos Argyris

机构信息

Henry Dunant Hospital, 107 Mesogeion Ave, 11526, Athens, Greece.

出版信息

Hepatogastroenterology. 2003 May-Jun;50(51):843-5.

PMID:12828101
Abstract

Mucormycosis is an opportunistic fungal infection caused by Mucorales. The disease is uncommon and produces serious and rapidly fatal infection in diabetic or immunocompromised patients. The classical presentation of rhinocerebral mucormycosis is involvement of nasal mucosa with invasion of paranasal sinuses and orbit. Early diagnosis is based on (direct) histological examination and computed tomography scan. Unfortunately the clinical signs and symptoms do not occur in all cases. A high index of suspicion is needed not only in typical groups of immunocompromised patients or diabetics, but also in patients with serious chronic diseases. We report a patient who was not diabetic, but she had a history of cirrhosis and well compensated renal failure.

摘要

毛霉病是一种由毛霉目真菌引起的机会性真菌感染。该疾病并不常见,在糖尿病患者或免疫功能低下的患者中会引发严重且迅速致命的感染。鼻脑型毛霉病的典型表现是鼻黏膜受累,并侵犯鼻窦和眼眶。早期诊断基于(直接)组织学检查和计算机断层扫描。不幸的是,并非所有病例都会出现临床体征和症状。不仅在典型的免疫功能低下患者群体或糖尿病患者中,而且在患有严重慢性疾病的患者中,都需要高度怀疑。我们报告了一名非糖尿病患者,但她有肝硬化病史且肾功能衰竭代偿良好。

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引用本文的文献

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Epidemiology of Mucormycosis in Greece; Results from a Nationwide Prospective Survey and Published Case Reports.希腊毛霉病的流行病学;一项全国性前瞻性调查及已发表病例报告的结果
J Fungi (Basel). 2023 Mar 29;9(4):425. doi: 10.3390/jof9040425.
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Invasive rhinocerebral mucormycosis in a patient with liver cirrhosis leading to fatal massive stroke.一名肝硬化患者发生侵袭性鼻脑毛霉菌病,导致致命的大面积中风。
Med Mycol Case Rep. 2018 Sep 21;22:69-73. doi: 10.1016/j.mmcr.2018.09.006. eCollection 2018 Dec.
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Rare Orbital Infections ~ State of the Art ~ Part II.
罕见眼眶感染——最新进展——第二部分。
J Ophthalmic Vis Res. 2018 Apr-Jun;13(2):183-190. doi: 10.4103/jovr.jovr_202_17.
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Invasive mucormycosis in a patient with liver cirrhosis: case report and review of the literature.一名肝硬化患者的侵袭性毛霉病:病例报告及文献复习
Hepat Mon. 2013 Aug 11;13(8):e10858. doi: 10.5812/hepatmon.10858. eCollection 2013.
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Coinfection of pulmonary mucormycosis and aspergillosis presenting as bilateral vocal cord palsy.肺部毛霉菌病和曲霉菌病合并感染表现为双侧声带麻痹。
BMJ Case Rep. 2013 Aug 20;2013:bcr2013009615. doi: 10.1136/bcr-2013-009615.
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Pulmonary mucormycosis: an emerging infection.肺毛霉病:一种新出现的感染性疾病。
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A mucormycosis case in a cirrhotic patient successfully treated with posaconazole and review of published literature.一名肝硬化患者的毛霉菌病病例经泊沙康唑成功治疗并复习文献
Mycopathologia. 2012 Dec;174(5-6):499-504. doi: 10.1007/s11046-012-9561-8. Epub 2012 Jun 29.