Mahadevaiah Arun H, Rajagopalan Natarajan, Patil Mahantesh, C Shivaprasad
Department of Pulmonology and Critical Care, Narayana Hrudayalaya Hospital, Bangalore, Karnataka, India.
BMJ Case Rep. 2013 Aug 20;2013:bcr2013009615. doi: 10.1136/bcr-2013-009615.
Invasive pulmonary coinfection with Mucor and Aspergillus is rare. Bilateral vocal cord paralysis resulting from coinfection with these two fungi to our knowledge has not been reported in the literature. We report a young woman with diabetes who presented with symptoms of community acquired pneumonia in association with hoarseness of voice. Investigations revealed air space consolidation of the right upper lobe, evidence of mediastinal involvement extending into the paratracheal space and entrapment of right upper lobe pulmonary artery. Bronchoscopy revealed bilateral vocal cord paralysis and sloughing of mucosa of the right upper lobe bronchus and the bronchus intermedius. Microbiological and pathological results confirmed Mucor and Aspergillus. Extensive vascular and mediastinal involvement precludes surgical debridement. Despite aggressive medical management the patient deteriorated and died of respiratory failure. Strong suspicion of invasive fungal infections in immune compromised patients presenting with unresolving pneumonia and hoarseness of voice, early aggressive treatment is crucial for the patient survival.
毛霉和曲霉的侵袭性肺部混合感染较为罕见。据我们所知,文献中尚未报道过这两种真菌混合感染导致双侧声带麻痹的情况。我们报告了一名患有糖尿病的年轻女性,她出现了社区获得性肺炎的症状并伴有声音嘶哑。检查发现右上叶实变,有纵隔受累延伸至气管旁间隙的证据以及右上叶肺动脉受压。支气管镜检查显示双侧声带麻痹,右上叶支气管和中间支气管黏膜脱落。微生物学和病理学结果证实为毛霉和曲霉。广泛的血管和纵隔受累使手术清创无法进行。尽管进行了积极的药物治疗,患者病情仍恶化并死于呼吸衰竭。对于出现持续性肺炎和声音嘶哑的免疫功能低下患者,高度怀疑侵袭性真菌感染时,早期积极治疗对患者生存至关重要。