瓦朗戈龙，刺桐属植物艾迪生刺桐茎皮中的异黄酮抗炎成分。

Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.

作者信息

Talla Emmanuel, Njamen Dieudonné, Mbafor Joseph Tanyi, Fomum Zacharias Tanee, Kamanyi Albert, Mbanya Jean-Claude, Giner Rosa M, Recio M Carmen, Máñez Salvador, Ríos José Luis

机构信息

Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon.

出版信息

J Nat Prod. 2003 Jun;66(6):891-3. doi: 10.1021/np020599b.

DOI:10.1021/np020599b

PMID:12828487

Abstract

The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.

摘要

异戊烯基异黄酮瓦朗戈龙已从阿迪森刺桐的树皮中分离出来。这种化合物先前被认为是蛋白激酶A的强效抑制剂，在分别进行全身和局部给药后，对磷脂酶A2诱导的小鼠爪肿胀以及12-O-十四烷酰佛波醇-13-乙酸酯诱导的小鼠耳肿胀显示出显著的抗炎效果。