Poeggel G, Müller M, Seidel I, Rechardt L, Bernstein H G
Institute Neurobiology, Madgeburg, Germany.
J Cardiovasc Pharmacol. 1992;20 Suppl 12:S76-9. doi: 10.1097/00005344-199204002-00023.
The distribution of guanylate cyclase, phosphodiesterase, and NADPH-diaphorase [nitric oxide (NO) synthase] was studied in rat brain both at the light and electron microscopic level with special emphasis on the vascular system. We showed that the cGMP-generating enzyme is located in cells (glial cells and pericytes) surrounding cerebral vessels, but not in the endothelium. For NO synthase, a dual localization was observed. The enzyme is present in parts of the endothelium and in nerve endings apparently innervating larger brain vessels. We propose, therefore, that NO acts on guanylate cyclase both from a "synaptic" and endothelial source.
在大鼠脑中，我们通过光学显微镜和电子显微镜研究了鸟苷酸环化酶、磷酸二酯酶和NADPH-黄递酶（一氧化氮合酶）的分布情况，特别关注了血管系统。我们发现，产生环磷酸鸟苷（cGMP）的酶位于脑血管周围的细胞（神经胶质细胞和周细胞）中，而非内皮细胞中。对于一氧化氮合酶，我们观察到其具有双重定位。该酶存在于部分内皮细胞以及明显支配较大脑血管的神经末梢中。因此，我们推测一氧化氮通过“突触”和内皮来源作用于鸟苷酸环化酶。
