Shimosegawa T, Abe T, Satoh A, Asakura T, Yoshida K, Koizumi M, Toyota T
Third Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan.
Neurosci Lett. 1992 Dec 14;148(1-2):67-70. doi: 10.1016/0304-3940(92)90806-i.
To clarify the role of nitric oxide (NO) in the pancreas, we histochemically investigated NADPH-diaphorase, a marker for NO synthase, in the rat pancreas. NADPH-diaphorase activity was localized in the neurons and endothelium of vessels. The nerve fibers with NADPH-diaphorase activity were observed in both the exocrine and the endocrine pancreas associated chiefly with the vascular systems. Most nerve cell bodies (98.5%) within the pancreatic parenchyma showed strong activity for this enzyme. These results suggest that NO may participate in the hemodynamic control of the pancreas and in the neuronal regulation of pancreatic exocrine and endocrine functions.
为阐明一氧化氮（NO）在胰腺中的作用，我们采用组织化学方法研究了大鼠胰腺中作为NO合酶标志物的还原型辅酶Ⅱ-黄递酶（NADPH-diaphorase）。NADPH-黄递酶活性定位于血管的神经元和内皮细胞。在与血管系统主要相关的外分泌部和内分泌部胰腺中均观察到具有NADPH-黄递酶活性的神经纤维。胰腺实质内的大多数神经细胞体（98.5%）对此酶表现出强活性。这些结果提示，NO可能参与胰腺的血流动力学调控以及胰腺外分泌和内分泌功能的神经调节。
