Foster Philip P, Boriek Aladin M, Butler Bruce D, Gernhardt Michael L, Bové Alfred A
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Aviat Space Environ Med. 2003 Jun;74(6 Pt 2):B1-64.
A patent foramen ovale (PFO) has been reported to be an important risk factor for cardioembolic cerebrovascular accidents through paradoxical systemic embolization, and it provides one potential mechanism for the paradoxical systemic embolization of venous gas bubbles produced after altitude or hyperbaric decompressions. Here, we present in a single document a summary of the original findings and views from authors in this field. It is a comprehensive review of 145 peer-reviewed journal articles related to PFO that is intended to encourage reflection on PFO detection methods and on the possible association between PFO and stroke. There is a heightened debate on whether aviators, astronauts, and scuba divers should go through screening for PFO. Because it is a source of an important controversy, we prefer to present the findings in the format of a neutral bibliographic review independent of our own opinions. Each cited peer-reviewed article includes a short summary in which we attempt to present potential parallels with the pathophysiology of decompression bubbles. Two types of articles are summarized, as follows. First, we report the original clinical and physiological findings which focus on PFO. The consistent reporting sequence begins by describing the method of detection of PFO and goal of the study, followed by bulleted results, and finally the discussion and conclusion. Second, we summarize from review papers the issues related only to PFO. At the end of each section, an abstract with concluding remarks based on the cited articles provides guidelines.
据报道，卵圆孔未闭（PFO）是心源性脑血管意外通过反常性全身栓塞的一个重要危险因素，它为海拔或高压减压后产生的静脉气泡反常性全身栓塞提供了一种潜在机制。在此，我们在一份文档中呈现该领域作者的原始研究结果和观点总结。这是对145篇与PFO相关的同行评审期刊文章的全面综述，旨在促使人们思考PFO检测方法以及PFO与中风之间可能存在的关联。关于飞行员、宇航员和潜水员是否应该接受PFO筛查的争论愈发激烈。由于这是一个重要争议的源头，我们更倾向于以独立于我们自身观点的中立文献综述形式呈现研究结果。每篇引用的同行评审文章都包含一个简短总结，我们试图在其中呈现与减压气泡病理生理学的潜在相似之处。总结了两种类型的文章，如下。首先，我们报告聚焦于PFO的原始临床和生理学研究结果。一致的报告顺序先是描述PFO的检测方法和研究目的，接着是列出的结果，最后是讨论和结论。其次，我们从综述论文中总结仅与PFO相关的问题。在每个部分结尾，基于引用文章给出的带有总结性评论的摘要提供了指导方针。
