[γ-氨基丁酸能应激限制系统激活剂丙戊酸钠（阿西普洛尔）和乙磺半胱氨酸对心律失常患者的临床血液动力学影响]
[The clinico-hemodynamic effects of the activator of the GABA-ergic stress-limiting system sodium valproate (acediprol) and etatsizin in patients with cardiac arrhythmias].
作者信息
Skibitskiĭ V V, Meerson F Z, Petrova T R, Meliukhova N E
出版信息
Kardiologiia. 1992 Jul;32(7-8):21-5.
Hemodynamic and antiarrhythmic effects of acediprol and ethacizine were examined in 51 patients with premature ventricular contraction concurrent with neurocirculatory dystonia and coronary heart disease. It was ascertained that acediprol exerted a positive inotropic action and ethacizine lowered myocardial contractility. Acediprol therapy prevents or attenuates the hypokinetic and arrhythmogenic effects of stimulated stress in patients with ischemic and non-ischemic arrhythmias. The preventive antiarrhythmic effect of acediprol is the most pronounced in patients with neurocirculatory dystonia. Ethacizine fails to improve hemodynamic supply of the stress test and enhances stress-related hypodynamia in some patients.
在51例患有室性早搏并发神经循环性肌张力障碍和冠心病的患者中，研究了醋地普罗和乙胺碘呋酮的血流动力学及抗心律失常作用。已确定醋地普罗具有正性肌力作用，而乙胺碘呋酮降低心肌收缩力。醋地普罗治疗可预防或减轻缺血性和非缺血性心律失常患者中应激刺激引起的运动功能减退和致心律失常作用。醋地普罗的预防性抗心律失常作用在神经循环性肌张力障碍患者中最为明显。乙胺碘呋酮未能改善应激试验的血流动力学供应，反而在一些患者中加重了与应激相关的动力不足。
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