Meerson F Z, Skibitskiĭ V V
Kardiologiia. 1992 Apr;32(4):25-30.
The antiarrhythmic effects produced by activators of the body's stress-limiting systems were comparatively evaluated in patients with cardiac arrhythmias of ischemic and non-ischemic etiology. Acediprol, gidazepam, and befol were found to be beneficial in ventricular premature contraction when psychoemotional stress was simulated, as evidenced by 24-hour monitoring. The most pronounced protective therapeutical effect of the drugs was observed in patients with arrhythmias of extracoronary origin and in individuals with a marked arrhythmogenic effect of stress. Gidazepam was shown to suppress the provocative arrhythmogenic effect of the stress test.
对患有缺血性和非缺血性病因心律失常的患者，比较评估了机体应激限制系统激活剂产生的抗心律失常作用。通过24小时监测发现，在模拟心理情绪应激时，醋丙洛尔、吉地西泮和贝福尔对室性早搏有益。在冠状动脉外起源心律失常的患者以及应激具有明显致心律失常作用的个体中，观察到这些药物最显著的保护性治疗效果。已证实吉地西泮可抑制应激试验的诱发性致心律失常作用。
