Ylönen Katriina, Saloranta Carola, Kronberg-Kippilä Carina, Groop Leif, Aro Antti, Virtanen Suvi M
Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, Helsinki, Finland.
Diabetes Care. 2003 Jul;26(7):1979-85. doi: 10.2337/diacare.26.7.1979.
To study cross-sectional associations of dietary fiber intake with insulin resistance, insulin secretion, and glucose tolerance in a population at high risk for type 2 diabetes.
The subjects consisted of 248 male and 304 female adult nondiabetic relatives of patients with type 2 diabetes. Dietary intake was measured by means of two 3-day food records. Associations of total, water-insoluble, and water-soluble fiber with measures of glucose metabolism based on an oral glucose tolerance test, were analyzed by multiple linear regression analysis adjusting for sex, age, length of education, physical activity, BMI, waist-to-hip ratio, systolic blood pressure, and serum triglyceride and HDL cholesterol concentrations. The homeostasis model assessment insulin resistance index, the incremental 30-min serum insulin concentration divided by the incremental 30-min glucose concentration, and fasting and 2-h glucose concentrations were the outcome variables.
The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)]. Fiber variables were unrelated to insulin secretion and plasma glucose concentrations.
The results support evidence that a high intake of dietary fiber is associated with enhanced insulin sensitivity and therefore may have a role in the prevention of type 2 diabetes.
研究膳食纤维摄入量与2型糖尿病高危人群胰岛素抵抗、胰岛素分泌及葡萄糖耐量之间的横断面关联。
研究对象包括248名男性和304名女性2型糖尿病患者的非糖尿病成年亲属。通过两份3天的饮食记录来测量饮食摄入量。基于口服葡萄糖耐量试验，采用多元线性回归分析，对性别、年龄、教育年限、身体活动、体重指数、腰臀比、收缩压以及血清甘油三酯和高密度脂蛋白胆固醇浓度进行校正，分析总膳食纤维、水不溶性膳食纤维和水溶性膳食纤维与葡萄糖代谢指标之间的关联。稳态模型评估胰岛素抵抗指数、30分钟血清胰岛素浓度增加值除以30分钟葡萄糖浓度增加值以及空腹和2小时血糖浓度为结局变量。
总膳食纤维以及水不溶性膳食纤维和水溶性膳食纤维的饮食摄入量与胰岛素抵抗呈负相关：-0.17（0.07），P = 0.012；-0.15（0.07），P = 0.024；-0.14（0.07），P = 0.049[回归系数（标准误）]。膳食纤维变量与胰岛素分泌和血浆葡萄糖浓度无关。
结果支持高膳食纤维摄入量与增强胰岛素敏感性相关的证据，因此可能在预防2型糖尿病中发挥作用。
