Vázquez-Ruiz Zenaida, Martínez-González Miguel Ángel, Vitelli-Storelli Facundo, Bes-Rastrollo Maira, Basterra-Gortari Francisco Javier, Toledo Estefanía
Department of Preventive Medicine and Public Health, Instituto de Investigación Sanitaria de Navarra (IdiSNA), University of Navarra, 31008 Pamplona, Spain.
Biomedical Research Network Centre for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029 Madrid, Spain.
Antioxidants (Basel). 2023 Feb 17;12(2):507. doi: 10.3390/antiox12020507.
The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could help to better understand the mechanisms implicated in this protection. We evaluated the association between dietary intake of PC and the risk of T2D in a relatively young cohort of 17,821 Spanish participants initially free of T2D, through the University of Navarra Follow-up Project ("Seguimiento Universidad de Navarra" or SUN cohort) after 10 years of median follow-up using time-dependent Cox models. Intake of PC was estimated at baseline and repeatedly at 10-year follow-up using a 136-item validated food frequency and the Phenol-Explorer database. The incidence of T2D was identified by a biennial follow-up, and only medically confirmed cases were included. During 224,751 person-years of follow-up, 186 cases of T2D were confirmed. A suboptimal intake of stilbenes was independently associated with a higher risk of T2D in subjects over 50 years (HR: 1.75, 95% CI: 1.06-2.90, value < 0.05) after adjusting for potential confounders. Our results suggest that a moderate-high intake of stilbenes can decrease the risk of developing T2D in subjects over 50 years in our cohort.
近几十年来，全球2型糖尿病（T2D）的发病率一直在稳步上升。地中海饮食模式已显示出对T2D风险的预防作用。评估地中海队列中生物活性化合物（如酚类化合物（PC））之间的关联，有助于更好地理解这种保护作用所涉及的机制。我们通过纳瓦拉大学随访项目（“Seguimiento Universidad de Navarra”或SUN队列），在对17821名最初无T2D的西班牙参与者进行了10年的中位随访后，使用时间依赖性Cox模型，评估了PC的饮食摄入量与T2D风险之间的关联。在基线时以及在10年随访时使用136项经过验证的食物频率和酚类化合物探索者数据库，对PC的摄入量进行了估计。通过两年一次的随访确定T2D的发病率，仅纳入经医学确认的病例。在224751人年的随访期间，确诊了186例T2D病例。在调整潜在混杂因素后，对于50岁以上的受试者，芪类化合物摄入不足与T2D风险较高独立相关（风险比：1.75，95%置信区间：1.06 - 2.90，P值<0.05）。我们的结果表明，在我们的队列中，适度高剂量摄入芪类化合物可降低50岁以上受试者患T2D的风险。
