Amon R B, Lis A W, Hanifin J M
Arch Dermatol. 1975 Dec;111(12):1581-4.
Idoxuridine has been used for many years in the treatment of herpex simplex infections of the eye. Use of the drug for herpes simplex infection of the skin is increasing. Ophthalmologists have noted occasional conjunctival and corneal irritant reactions, but no true delayed cutaneous hypersensitivity has been verified. We report four cases of allergic contact dermatitis from idoxuridine, sensitized by both eye and skin applications. Cross reactivity to brominated and chlorinated, but not fluorinated, pyrimidine analogues is noted. Extensive patch testing indicates the general relationship between the structure of pyrimidine compounds and their antigenic cross reactivity.
碘苷多年来一直用于治疗眼部单纯疱疹感染。该药物用于皮肤单纯疱疹感染的情况正在增加。眼科医生注意到偶尔会出现结膜和角膜刺激反应，但尚未证实有真正的迟发性皮肤过敏反应。我们报告了4例因碘苷引起的过敏性接触性皮炎病例，这些病例通过眼部和皮肤用药致敏。注意到对溴化和氯化但非氟化嘧啶类似物有交叉反应。广泛的斑贴试验表明了嘧啶化合物的结构与其抗原交叉反应之间的一般关系。
