Brittinger G, Engelhard M
Abteilung für Hämatologie, Universität Gesamthochschule Essen.
Verh Dtsch Ges Pathol. 1992;76:37-46.
The Kiel classification of non-Hodgkin lymphomas (NHL) identifies distinct entities by morphological and immunological criteria, subdivided into those of low and high grade malignancy and of B- or T-cell subtype. Numerous clinical studies have proven the clinical and prognostic relevance of this classification scheme although the degree of malignancy alone cannot be automatically equated with prognosis. Thus, histological low grade malignancy correlates with favorable response to therapy in all, but with long term survival only in some clearly defined low grade NHL and final cure is achieved in none of them so far. High grade malignancy corresponds to the aggressive spontaneous course of these NHL but is contrasted with the mostly favorable response to therapy and the chance of cure. The immunological T-cell subtype is clearly associated with an inferior prognosis. Additional biological features of NHL, namely chromosomal aberrations and the status of clonality will contribute to a more differentiated view of NHL and will possibly prove to bear prognostic potential.
非霍奇金淋巴瘤（NHL）的 Kiel 分类通过形态学和免疫学标准识别不同的实体，分为低级别和高级别恶性肿瘤以及 B 细胞或 T 细胞亚型。众多临床研究已证实该分类方案的临床和预后相关性，尽管仅恶性程度不能自动等同于预后。因此，组织学上的低级别恶性肿瘤与对所有治疗的良好反应相关，但仅在一些明确定义的低级别 NHL 中与长期生存相关，迄今为止尚无一种能实现最终治愈。高级别恶性肿瘤对应于这些 NHL 的侵袭性自然病程，但与对治疗的大多良好反应和治愈机会形成对比。免疫 T 细胞亚型显然与较差的预后相关。NHL 的其他生物学特征，即染色体畸变和克隆性状态，将有助于对 NHL 有更分化的认识，并可能证明具有预后潜力。
