Krzywda Szymon, Brzozowski Andrzej M, Al-Safty Roisin, Welchman Rebecca, Mee Maureen, Dawson Simon, Fujita Jun, Higashitsuji Hiroaki, Mayer R John, Wilkinson Anthony J
Department of Chemistry, University of York, York YO10 5YW, England.
Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1294-5. doi: 10.1107/s0907444903009892. Epub 2003 Jun 27.
Gankyrin is an oncoprotein overexpressed in hepatocarcinoma cells that binds to the cell-cycle regulator CDK4 and the S6b ATPase subunit of the regulatory component of the proteasome. It belongs to the family of ankyrin-repeat proteins that appear to mediate protein-protein interactions in diverse biochemical processes. Gankyrin has been crystallized from polyethylene glycol solutions and diffraction data have been obtained from these crystals that extend to 2.1 A spacing.
甘基瑞因是一种在肝癌细胞中过表达的癌蛋白，它与细胞周期调节因子CDK4以及蛋白酶体调节成分的S6b ATP酶亚基结合。它属于锚蛋白重复序列蛋白家族，该家族蛋白似乎在多种生化过程中介导蛋白质-蛋白质相互作用。甘基瑞因已从聚乙二醇溶液中结晶出来，并从这些晶体中获得了延伸至2.1埃间距的衍射数据。
