Shakib Sepehr, George Alison
Department of Clinical Pharmacology, Royal Adelaide Hospital, University of Adelaide, South Australia.
Aust Fam Physician. 2003 Jun;32(6):438-41.
Having decided on a drug class, an individual drug needs to be chosen.
This article discusses the same four factors used in deciding the generic drug within a class as well as between different drug classes: efficacy, safety, suitability, and cost.
The example of hypertension will be used to illustrate the choice of individual drugs within beta blockers and calcium channel blockers. Although a large number of options exist within each class, by considering the above factors, the choice is narrowed to only 1-2 preferred options. These drugs should then be added to the P- or Personal-drug list. By only prescribing agents on the P-drug list, the prescriber will become more familiar with their closing, adverse effects, and interactions, resulting in improved patient outcomes. Also when a new drug becomes available, it clearly needs to be better for the patient in terms of these factors, before it is added to the P-drug list.
在选定一类药物后，需要选择一种具体的药物。
本文讨论了在选择同一类药物以及不同类药物中的通用药物时所使用的相同四个因素：疗效、安全性、适用性和成本。
将以高血压为例来说明在β受体阻滞剂和钙通道阻滞剂中选择具体药物的过程。虽然每一类药物都有大量选择，但通过考虑上述因素，选择范围可缩小至仅1 - 2种首选药物。然后应将这些药物添加到P类或个人药物清单中。仅开具P类药物清单上的药物，开处方者将更熟悉其用法、不良反应和相互作用，从而改善患者的治疗效果。此外，当有新药上市时，在将其添加到P类药物清单之前，显然在这些因素方面它需要对患者更有益。
