前促甘丙肽mRNA在猴海马结构中的定位。

Localization of preprogalanin mRNA in the monkey hippocampal formation.

作者信息

Evans H F, Huntley G W, Morrison J H, Shine J, Paxinos G

机构信息

Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, NSW, Australia.

出版信息

Neurosci Lett. 1992 Nov 9;146(2):171-5. doi: 10.1016/0304-3940(92)90070-n.

DOI:10.1016/0304-3940(92)90070-n

PMID:1283450

Abstract

The existence of neurons expressing preprogalanin mRNA in the monkey hippocampal formation was demonstrated using in situ hybridization of a radio-labelled cRNA probe transcribed from human preprogalanin cDNA. Specific hybridization occurred in neurons of the hilus of the dentate gyrus, fields CA1-3 in Ammon's horn, subiculum, presubiculum, parasubiculum and occasionally in neurons of the entorhinal cortex. These findings suggest that galanin is synthesized by neurons intrinsic to the monkey hippocampal formation.

摘要

利用从人前甘丙肽cDNA转录而来的放射性标记cRNA探针进行原位杂交，证实了猴海马结构中存在表达前甘丙肽mRNA的神经元。在齿状回门区、海马角的CA1 - 3区、下托、前下托、旁下托的神经元中出现特异性杂交，偶尔在内嗅皮质的神经元中也有。这些发现表明甘丙肽是由猴海马结构固有的神经元合成的。