Bloms P, Musshoff U, Madeja M, Müsch-Nittel K, Kuhlmann D, Spener F, Speckmann E J
Institut für Physiologie, Münster, FRG.
Neurosci Lett. 1992 Dec 7;147(2):155-8. doi: 10.1016/0304-3940(92)90583-s.
The effects of the epileptogenic substance pentylenetetrazol (PTZ) on ligand operated membrane channels were studied. For this purpose serotonin (5-HT) sensitive channels were expressed in RNA injected oocytes of Xenopus laevis. With simultaneous application of both substances, the response to 5-HT was reduced and eventually abolished by PTZ with increasing concentrations (5-100 mM). A reduction of the 5-HT response also appeared when PTZ was applied in various intervals (15 and 240 s) before 5-HT. It may be assumed that PTZ produces a component of its epileptogenic effect by acting on ligand operated membrane channels.
研究了致痫物质戊四氮（PTZ）对配体门控膜通道的影响。为此，在注射了RNA的非洲爪蟾卵母细胞中表达了5-羟色胺（5-HT）敏感通道。同时应用这两种物质时，随着PTZ浓度增加（5-100 mM），对5-HT的反应降低，最终被消除。当在5-HT之前的不同时间间隔（15和240秒）应用PTZ时，5-HT反应也出现降低。可以推测，PTZ通过作用于配体门控膜通道产生其致痫作用的一部分。
