Bloms-Funke P, Madeja M, Musshoff U, Speckmann E J
Institute fur Physiologie der Westfalischen Wilhelms-Universitat Munster, Germany.
Neurosci Lett. 1996 Feb 23;205(2):115-8. doi: 10.1016/0304-3940(96)12391-0.
The convulsive agent pentylenetetrazol (PTZ) antagonized gamma-aminobutyric acid (GABA)-induced membrane currents on RNA-injected Xenopus oocytes with both extra- and intracellular applications. With extracellular administration PTZ enters the cell within a few minutes and reaches concentrations in the millimolar range. The permeability of the plasma membrane makes it possible for systemically applied PTZ to elicit its effect on the GABA-induced currents via extra- as well as intracellular sites of action.
惊厥剂戊四氮（PTZ）在对注射了RNA的非洲爪蟾卵母细胞进行细胞外和细胞内应用时，均能拮抗γ-氨基丁酸（GABA）诱导的膜电流。通过细胞外给药，PTZ在几分钟内进入细胞，并达到毫摩尔范围内的浓度。质膜的通透性使得全身应用的PTZ能够通过细胞外和细胞内作用位点对GABA诱导的电流产生影响。
