Bloms-Funke P, Musshoff U, Madeja M, Spener F, Speckmann E J
Institut für Physiologie, Westfälischen Wilhelms-Universität, Münster, Germany.
Neurosci Lett. 1994 Nov 7;181(1-2):161-4. doi: 10.1016/0304-3940(94)90584-3.
The effects of the epileptogenic agent pentylenetetrazol (PTZ) on current responses to glutamate (Glu) and to the Glu receptor agonist N-methyl-D-aspartate (NMDA), kainate (KA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and quisqualate (QA) were studied on RNA-injected Xenopus oocytes. PTZ antagonized the reactions to Glu as well as to NMDA, KA, AMPA and QA. With increasing concentration of AMPA, however, the depressive effect of PTZ turned to an augmentation. The complete change from a decreasing to an increasing effect of PTZ with elevated agonist concentration was unique for current responses by AMPA.
在注射RNA的非洲爪蟾卵母细胞上研究了致痫剂戊四氮（PTZ）对谷氨酸（Glu）以及对Glu受体激动剂N-甲基-D-天冬氨酸（NMDA）、海人酸（KA）、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）和quisqualate（QA）电流反应的影响。PTZ拮抗对Glu以及对NMDA、KA、AMPA和QA的反应。然而，随着AMPA浓度增加，PTZ的抑制作用转变为增强作用。随着激动剂浓度升高，PTZ作用从降低转变为增强，这种完全转变在AMPA引起的电流反应中是独特的。
