Sul Young-Taeg
Department of Biomaterials Sciences, University of Göteborg, Medicinaregatan 8b, PO Box 412, S-405 30, Göteborg, Sweden.
Biomaterials. 2003 Oct;24(22):3893-907. doi: 10.1016/s0142-9612(03)00261-8.
The aim of the present study is to investigate bone tissue reactions to various surface oxide properties, in particular to different surface oxide chemistry of oxidized titanium implants (grade 1). One control and three test screw-shaped implant groups were prepared. Controls were turned implants. Test implants, i.e. S implants, P implants and Ca implants were by the micro-arc oxidation (MAO) method. The surface characterizations were performed with X-ray photoelectron spectroscopy, Auger electron spectroscopy, scanning electron microscopy, X-ray diffractometry and TopScan 3D. Eighty implants were inserted in the femora and tibiae of ten mature New Zealand white rabbits for 6 weeks. The removal torque values (RTQ) showed significant differences between S implants and controls (p=0.022), Ca implants and controls (p=0.0001), Ca implants and P implants (p=0.005) but did not show significant differences between the others (p>0.05). In addition, the bone to metal contact (BMC) around the entire implants demonstrated 186% increase in S implants, 232% increase in P implants and 272% increase in Ca implants when compared to the paired control groups. Based on the comparative analysis of the surface characteristics resulting different bone responses between all groups, it was concluded that surface chemistry and topography separately or together play important roles in the bone response to the oxidized implants.
本研究的目的是调查骨组织对各种表面氧化物特性的反应，特别是对氧化钛植入物（1级）不同表面氧化物化学性质的反应。制备了一组对照和三组测试螺旋形植入物。对照组为车削植入物。测试植入物，即S植入物、P植入物和Ca植入物，采用微弧氧化（MAO）方法制备。使用X射线光电子能谱、俄歇电子能谱、扫描电子显微镜、X射线衍射仪和TopScan 3D进行表面表征。将80个植入物植入10只成年新西兰白兔的股骨和胫骨中6周。去除扭矩值（RTQ）显示S植入物与对照组之间存在显著差异（p = 0.022），Ca植入物与对照组之间存在显著差异（p = 0.0001），Ca植入物与P植入物之间存在显著差异（p = 0.005），但其他组之间无显著差异（p>0.05）。此外，与配对对照组相比，整个植入物周围的骨与金属接触（BMC）在S植入物中增加了186%，在P植入物中增加了232%，在Ca植入物中增加了272%。基于对所有组之间不同骨反应的表面特征的比较分析，得出结论：表面化学和形貌单独或共同在骨对氧化植入物的反应中起重要作用。
