Shiraishi T, Atsumi S, Yatani R
Department of Pathology, Mie University School of Medicine, Japan.
Adv Exp Med Biol. 1992;324:7-16. doi: 10.1007/978-1-4615-3398-6_2.
Metastatic prostate carcinomas in autopsy cases from three populations 49 cases of indigenous Japanese, 29 cases of Japanese Americans and 14 from whites in Hawaii) were compared in terms of their clinicopathological, immunohistochemical (tenascin and ras p21) and lectin binding (Helix Pomatia antigen, HPA) properties. Only the clinicopathological features were analyzed in the cases of whites in Hawaii. The results indicate that poorly differentiated carcinoma is less common, whereas distant metastasis is more frequent, in indigenous Japanese. Some of the Japanese-American cases with poorly differentiated carcinomas did not show any distant metastases. HPA and ras p21 expression are more common, but tenascin is less common in indigenous Japanese. HPA expression is more common in cases with metastasis, especially with metastasis to the bone and other organs, than nonmetastatic cases. Prostatic cancer cases in indigenous Japanese were more aggressive biologically than those in Japanese Americans, but no phenotypic differences were seen relevant to the presence or absence of bone metastases.
对来自三个人群（49例日本原住民、29例日裔美国人以及14例夏威夷白人）尸检病例中的转移性前列腺癌进行了临床病理、免疫组化（腱生蛋白和ras p21）以及凝集素结合（蜗牛凝集素抗原，HPA）特性方面的比较。仅对夏威夷白人病例的临床病理特征进行了分析。结果表明，低分化癌在日本原住民中较少见，而远处转移更为常见。一些低分化癌的日裔美国病例未出现任何远处转移。HPA和ras p21表达在日本原住民中更为常见，但腱生蛋白则较少见。与无转移病例相比，HPA表达在有转移的病例中更为常见，尤其是转移至骨骼和其他器官的病例。日本原住民的前列腺癌病例在生物学上比日裔美国人的病例更具侵袭性，但在有无骨转移方面未观察到表型差异。
