人脂肪组织和骨髓来源的多谱系细胞的比较。
Comparison of multi-lineage cells from human adipose tissue and bone marrow.
作者信息
De Ugarte Daniel A, Morizono Kouki, Elbarbary Amir, Alfonso Zeni, Zuk Patricia A, Zhu Min, Dragoo Jason L, Ashjian Peter, Thomas Bert, Benhaim Prosper, Chen Irvin, Fraser John, Hedrick Marc H
机构信息
Departments of Surgery and Orthopaedics, UCLA School of Medicine, Los Angeles, California, USA.
出版信息
Cells Tissues Organs. 2003;174(3):101-9. doi: 10.1159/000071150.
Our laboratory has recently characterized a population of cells from adipose tissue, termed processed lipoaspirate (PLA) cells, which have multi-lineage potential similar to bone-marrow-derived mesenchymal stem cells (MSCs). This study is the first comparison of PLA cells and MSCs isolated from the same patient. No significant differences were observed for yield of adherent stromal cells, growth kinetics, cell senescence, multi-lineage differentiation capacity, and gene transduction efficiency. Adipose tissue is an abundant and easily procured source of PLA cells, which have a potential like MSCs for use in tissue-engineering applications and as gene delivery vehicles.
我们实验室最近鉴定了一群来自脂肪组织的细胞，称为经处理的脂肪抽吸物（PLA）细胞，它们具有与骨髓间充质干细胞（MSC）相似的多向分化潜能。本研究首次对来自同一患者的PLA细胞和MSC进行了比较。在贴壁基质细胞产量、生长动力学、细胞衰老、多向分化能力和基因转导效率方面未观察到显著差异。脂肪组织是PLA细胞丰富且易于获取的来源，PLA细胞具有与MSC类似的潜力，可用于组织工程应用和作为基因递送载体。
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