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脊髓损伤后间充质干细胞对失衡微环境的调节进展

Progression of mesenchymal stem cell regulation on imbalanced microenvironment after spinal cord injury.

作者信息

Liu Yifan, Zhao Chenxi, Zhang Rong, Pang Yilin, Li Linquan, Feng Shiqing

机构信息

Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 107 West Wenhua Road, Lixia District, Jinan, 250012, Shandong, China.

Institute of Medical Sciences, The Second Hospital of Shandong University, Shandong University Center for Orthopaedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, Shandong, China.

出版信息

Stem Cell Res Ther. 2024 Oct 1;15(1):343. doi: 10.1186/s13287-024-03914-x.

DOI:10.1186/s13287-024-03914-x
PMID:39354635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446099/
Abstract

Spinal cord injury (SCI) results in significant neural damage and inhibition of axonal regeneration due to an imbalanced microenvironment. Extensive evidence supports the efficacy of mesenchymal stem cell (MSC) transplantation as a therapeutic approach for SCI. This review aims to present an overview of MSC regulation on the imbalanced microenvironment following SCI, specifically focusing on inflammation, neurotrophy and axonal regeneration. The application, limitations and future prospects of MSC transplantation are discussed as well. Generally, a comprehensive perspective is provided for the clinical translation of MSC transplantation for SCI.

摘要

脊髓损伤（SCI）会导致严重的神经损伤，并由于微环境失衡而抑制轴突再生。大量证据支持间充质干细胞（MSC）移植作为SCI治疗方法的有效性。本综述旨在概述脊髓损伤后间充质干细胞对失衡微环境的调节作用，特别关注炎症、神经营养和轴突再生。还讨论了间充质干细胞移植的应用、局限性和未来前景。总体而言，为脊髓损伤间充质干细胞移植的临床转化提供了一个全面的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/02db5e6ffa9c/13287_2024_3914_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/02bc35bc965b/13287_2024_3914_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/96fcde0c2bd4/13287_2024_3914_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/02db5e6ffa9c/13287_2024_3914_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/02bc35bc965b/13287_2024_3914_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/96fcde0c2bd4/13287_2024_3914_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2b/11446099/02db5e6ffa9c/13287_2024_3914_Fig3_HTML.jpg

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本文引用的文献

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Preconditioning of MSCs for Acute Neurological Conditions: From Cellular to Functional Impact-A Systematic Review.预处理间充质干细胞用于急性神经系统疾病：从细胞到功能影响的系统性评价。
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Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial.
硫化氢调节小胶质细胞极化并重塑损伤微环境以促进脊髓损伤后的功能恢复。
CNS Neurosci Ther. 2025 May;31(5):e70431. doi: 10.1111/cns.70431.
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BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury.骨髓间充质干细胞来源的外泌体通过miR-21a-5p/PELI1轴增强自噬来抑制脊髓损伤中巨噬细胞/小胶质细胞的焦亡。
Aging (Albany NY). 2024 Mar 11;16(6):5184-5206. doi: 10.18632/aging.205638.
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Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders.反应性星形胶质细胞与中枢神经系统（CNS）疾病中的新作用。
Cold Spring Harb Perspect Biol. 2024 Jul 1;16(7):a041356. doi: 10.1101/cshperspect.a041356.
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Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury.初始的 IL-10 产生主导了间充质干细胞支架在脊髓损伤中的治疗作用。
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