Atkinson J
Laboratoire de Pharmacologie Cardio-Vasculaire, Faculté de Pharmacie, Nancy, France.
Drugs. 1992;44 Suppl 1:111-8. doi: 10.2165/00003495-199200441-00021.
Pronounced vascular calcium overload, especially of compliance arteries, is an important aspect of aging, and of various age-related vascular diseases such as hypertension and atherosclerosis. The development of new drugs specifically aimed at attenuating the evolution and/or pathological consequences of vascular calcium overload is hindered by the paucity of animal models available. Although several laboratory animals exhibit vascular calcium overload, this evolves slowly and is far less marked than in man. Nevertheless, Fleckenstein and associates (1989) suggested a suitable animal model involving the treatment of young rats with vitamin D3 and nicotine; such treatment produces pronounced vascular calcium overload within a few weeks. This paper describes the cardiovascular effects of such treatment, and our preliminary attempts to pharmacologically modify vascular calcium overload and its cardiovascular consequences.
明显的血管钙超载，尤其是顺应性动脉的钙超载，是衰老以及各种与年龄相关的血管疾病（如高血压和动脉粥样硬化）的一个重要方面。由于可用动物模型的匮乏，开发专门用于减轻血管钙超载的进展和/或病理后果的新药受到了阻碍。尽管几种实验动物会出现血管钙超载，但这种情况发展缓慢，且远不如人类明显。然而，弗莱肯斯坦及其同事（1989年）提出了一种合适的动物模型，即给幼鼠用维生素D3和尼古丁进行处理；这样的处理在几周内就会产生明显的血管钙超载。本文描述了这种处理对心血管的影响，以及我们在药理学上改变血管钙超载及其心血管后果的初步尝试。
