（3'S）-3'-脱氧-3'-氟-3'-C-乙炔基胞苷的合成与生物学评价
Synthesis and biological evaluation of (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine.
作者信息
Clark Jeremy L, Clark Carey B, Mason J Christian
机构信息
Cejera, LLC, Birmingham, Alabama, USA.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):286-92. doi: 10.1080/15257770.2011.652753.
PMID:22444191
Abstract
The novel pyrimidine nucleoside, (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine (1) was synthesized from cytidine in seven steps. The key step in the synthesis was the introduction of the tertiary fluorine at the 3'-position. Compound 1 was evaluated in vitro against several RNA viruses.
摘要
新型嘧啶核苷（3'S）-3'-脱氧-3'-氟-3'-C-乙炔基胞苷（1）由胞苷经七步合成。合成中的关键步骤是在3'-位引入叔氟。化合物1在体外针对几种RNA病毒进行了评估。
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