患有包虫病儿童的血浆甲苯咪唑水平。

Plasma levels of mebendazole in children with hydatid disease.

作者信息

Toppare M F, Gocmen A, Kiper N

机构信息

Turkish Health and Therapy Foundation, Ankara.

出版信息

Ann Trop Paediatr. 1992;12(4):441-3. doi: 10.1080/02724936.1992.11747611.

DOI:10.1080/02724936.1992.11747611

PMID:1283675

Abstract

The plasma levels of mebendazole in children with hydatid cyst disease were measured with high pressure liquid chromatography. In 24 children who received mebendazole orally in a dose of 50 mg/kg, the mean (SD) level 4 hours later was 25.76(9.81) ng/ml (87.6(33) nanomole/l). This result was similar to those in most adult series. During more prolonged treatment, the plasma level 4 hours after the dose of the drug rose significantly with respect to the initial level (p < 0.05).

摘要

采用高压液相色谱法测定了包虫囊肿病患儿的甲苯咪唑血浆水平。在24名口服50mg/kg甲苯咪唑的儿童中，4小时后的平均（标准差）水平为25.76(9.81)ng/ml（87.6(33)纳摩尔/升）。该结果与大多数成人研究系列中的结果相似。在更长时间的治疗过程中，给药后4小时的血浆水平相对于初始水平显著升高（p<0.05）。