Shcherbakov A M, Kozlova T L, Bebris N K
Med Parazitol (Mosk). 1992 Sep-Dec(5-6):9-11.
Only two of the 75 patients with echinococcosis, treated with mebendazole in a dose of 50 mg/kg b. m. for 30 days (single course) and administered from 1 to 13 courses with intervals of 1 to 3 months, developed agranulocytosis eventuating in death in one female patient. Analysis of blood levels of mebendazole and its metabolites permits a hypothesis that high concentrations thereof may have a toxic effect on the bone marrow, inducing its hypoplasia, in subjects sensitive to these substances.
75例棘球蚴病患者接受甲苯达唑治疗，剂量为50mg/kg体重，疗程30天（单疗程），共进行1至13个疗程，疗程间隔为1至3个月，其中只有2例出现粒细胞缺乏症，1例女性患者因此死亡。对甲苯达唑及其代谢产物的血药浓度分析表明，对于对这些物质敏感的个体，其高浓度可能会对骨髓产生毒性作用，导致骨髓发育不全。
