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用甲苯咪唑(肠虫清)治疗肝和肺棘球蚴病

[Treatment of hepatic and pulmonary echinococcosis with mebendazole (Vermox)].

作者信息

Todorov T, Vutova K, Zografski B, Petkov D, Mechkov G

出版信息

Vutr Boles. 1987;26(6):61-8.

PMID:3439155
Abstract

The therapeutic efficacy of Mebendazole (Vermox) was studied in 13 patients: 8 with liver and 5 with pulmonary echinococcosis. The drug was given in a dose of 50-70 mg/kg body mass. Good therapeutic effect was found in 4 patients (2 with liver nad 2 with pulmonary echinococcosis), partial therapeutic efficiency was registered also in 4 patients (2 with liver and 2 with pulmonary echinococcosis) and failure in 5 patients. The drug was more effective in pulmonary echinococcosis, in younger and smaller cysts than in older cysts with thick walls and presence of filial cysts. The efficacy of the treatment is related to the drug plasma concentration but the results depend on the cysts condition, too. The careful examination of the patients--X-ray, ultrasonography and computer tomography--before, during and after the treatment ensures objective evaluation of the treatment results.

摘要

对13例患者的甲苯达唑(肠虫清)治疗效果进行了研究:其中8例为肝包虫病患者,5例为肺包虫病患者。给药剂量为50 - 70毫克/千克体重。4例患者(2例肝包虫病患者和2例肺包虫病患者)取得了良好的治疗效果,4例患者(2例肝包虫病患者和2例肺包虫病患者)也有部分治疗效果,5例患者治疗失败。该药物对肺包虫病、较年轻且较小的囊肿比对壁增厚且存在子囊的较老囊肿更有效。治疗效果与药物血浆浓度有关,但结果也取决于囊肿状况。在治疗前、治疗期间和治疗后对患者进行仔细检查——通过X射线、超声检查和计算机断层扫描——可确保对治疗结果进行客观评估。

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