George J N
Hematology-Oncology Section University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Blood Cells. 1992;18(3):501-11; discussion 512-5.
The literature on membrane glycoprotein changes occurring during platelet storage is reviewed. Technical problems which may have biased reports are clarified, and the consensus of current studies is established. The membrane alterations that occur during blood bank storage are reminiscent of the surface changes which result from platelet secretion: an increased surface concentration of GP IIb-IIIa and GMP-140, and the appearance of platelet membrane microparticles in the supernatant plasma. The clinical importance of these changes is unknown. Future directions for research on the structure and function of stored platelets are discussed.
本文综述了血小板储存期间发生的膜糖蛋白变化的相关文献。对可能影响报告结果的技术问题进行了阐明，并确立了当前研究的共识。血库储存期间发生的膜改变让人联想到血小板分泌所导致的表面变化：糖蛋白IIb-IIIa和GMP-140的表面浓度增加，以及上清血浆中出现血小板膜微粒。这些变化的临床重要性尚不清楚。文中还讨论了储存血小板结构和功能研究的未来方向。
