Ravichandran Kodi S
Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.
Cell. 2003 Jun 27;113(7):817-20. doi: 10.1016/s0092-8674(03)00471-9.
An evolutionarily conserved machinery exists for engulfment of apoptotic cells from worm to mammals. New observations suggest that corpse clearance is tightly linked to apoptosis and that dying cells use both recruitment and eat-me signals for phagocyte attraction and recognition.
从蠕虫到哺乳动物,存在一种进化上保守的机制用于吞噬凋亡细胞。新的观察结果表明,尸体清除与细胞凋亡紧密相关,并且垂死的细胞利用招募信号和“吃我”信号来吸引和识别吞噬细胞。