Liu Zaoqu, Li Yan, Ren Yuqing, Chen Jingqi, Weng Siyuan, Zhou Zhaokai, Luo Peng, Chen Quan, Xu Hui, Ba Yuhao, Zuo Anning, Liu Shutong, Zhang Yuyuan, Pan Teng, Han Xinwei
Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China.
Aging Cell. 2025 Feb;24(2):e14467. doi: 10.1111/acel.14467. Epub 2025 Jan 3.
From embryogenesis to aging, billions of cells perish daily in mammals. The multistep process by which phagocytes engulf these deceased cells without eliciting an inflammatory response is called efferocytosis. Despite significant insights into the fundamental mechanisms of efferocytosis, its implications in disorders such as aging and cancer remain elusive. Upon summarizing and analyzing existing studies on efferocytosis, it becomes evident that efferocytosis is our friend in resolving inflammation, yet it transforms into our foe by facilitating tumor development and metastasis. This review illuminates recent discoveries regarding the emerging mechanisms of efferocytosis in clearing apoptotic cells, explores its connections with aging, examines its influence on tumor development and metastasis, and identifies the regulatory factors of efferocytosis within the tumor microenvironment. A comprehensive understanding of these efferocytosis facets offers insights into crucial physiological and pathophysiological processes, paving the way for innovative therapeutic approaches to combat aging and cancer.
从胚胎发生到衰老，哺乳动物每天有数十亿细胞死亡。吞噬细胞吞噬这些死亡细胞而不引发炎症反应的多步骤过程称为胞葬作用。尽管对胞葬作用的基本机制有了重要认识，但其在衰老和癌症等疾病中的影响仍不明确。在总结和分析关于胞葬作用的现有研究后，很明显胞葬作用在解决炎症方面是我们的朋友，但它通过促进肿瘤发展和转移而变成了我们的敌人。这篇综述阐述了关于胞葬作用清除凋亡细胞新机制的最新发现，探讨了其与衰老的联系，研究了其对肿瘤发展和转移的影响，并确定了肿瘤微环境中胞葬作用的调节因子。对胞葬作用这些方面的全面理解为关键的生理和病理生理过程提供了见解，为对抗衰老和癌症的创新治疗方法铺平了道路。
