巨噬细胞如何利用细胞外钙网蛋白追踪猎物。
How macrophages use extracellular calreticulin to chase their prey.
作者信息
Zhao Liwei, Liu Peng, Kepp Oliver, Kroemer Guido
机构信息
Centre de Recherche des Cordeliers, Université Paris Cité, Sorbonne Université, Inserm, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, France.
INSERM US23/CNRS UAR 3655, Université Paris-Saclay, Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
出版信息
Oncoimmunology. 2025 Dec;14(1):2533494. doi: 10.1080/2162402X.2025.2533494. Epub 2025 Jul 12.
Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity.
最近的研究发现表明，巨噬细胞通过NEU1去唾液酸化靶细胞并释放组织蛋白酶切割的钙网蛋白（CALR）来标记它们以供吞噬，从而积极控制清除过程。这揭示了CALR作为免疫激活剂或抑制剂的双重作用，具体取决于其形式和背景，对癌症免疫具有不同的影响。
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