Kwiatkowski Adam V, Gertler Frank B, Loureiro Joseph J
Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Trends Cell Biol. 2003 Jul;13(7):386-92. doi: 10.1016/s0962-8924(03)00130-2.
Regulation of cytoskeletal dynamics is required to coordinate cell movement, adhesion and shape change. The Ena/VASP protein family is thought to play an important role in linking signaling pathways to remodeling of the actin cytoskeleton. This review will examine the mechanisms by which Ena/VASP function might control actin dynamics and how these proteins are linked to various signaling pathways.
细胞骨架动力学的调控对于协调细胞运动、黏附和形状变化是必需的。Ena/VASP蛋白家族被认为在将信号通路与肌动蛋白细胞骨架重塑相联系方面发挥着重要作用。本综述将探讨Ena/VASP功能可能控制肌动蛋白动力学的机制，以及这些蛋白如何与各种信号通路相联系。
