Morrison John A, Barton Bruce A, Biro Frank M, Sprecher Dennis L
Cincinnati Children's Hospital Medial Center, Cincinnati, Ohio, USA.
J Pediatr. 2003 Jun;142(6):637-42. doi: 10.1067/mpd.2003.246.
To determine the role of increasing free testosterone and estradiol in pubertal changes in male lipids.
We conducted a 3-year, longitudinal, observation study with biannual visits of 251 black and 285 white boys who were 10 to 15 years of age at enrollment. Sex hormones, lipid parameters, and body composition measures were obtained according to a standard protocol. The body mass index (kg/m(2)) was used to characterize obesity.
White boys had higher triglycerides, lower high-density lipoprotein cholesterol (HDL-C), lower apolipoprotein (apo)AI, and higher apoB than black boys. In boys of both races, increased body mass index was associated with increases in triglycerides, low-density lipoprotein cholesterol, apoB and decreases in HDL-C and apoAII. Within this framework, increased free testosterone was associated with increased apoB and decreased HDL-C and apoAI, whereas increased estradiol was associated with increased HDL-C and decreased triglycerides, low-density lipoprotein cholesterol, and apoB.
Changes in sex steroid hormones have significant effects on changes in lipid parameters-increasing free testosterone levels has atherogenic effects and increasing estradiol has antiatherogenic effects.
确定游离睾酮和雌二醇增加在男性青春期脂质变化中的作用。
我们进行了一项为期3年的纵向观察研究，对251名黑人男孩和285名白人男孩进行了每半年一次的随访，这些男孩在入组时年龄为10至15岁。根据标准方案获取性激素、脂质参数和身体成分测量值。使用体重指数（kg/m²）来表征肥胖。
白人男孩的甘油三酯水平较高，高密度脂蛋白胆固醇（HDL-C）较低，载脂蛋白（apo）AI较低，apoB较高，而黑人男孩则相反。在两个种族的男孩中，体重指数增加与甘油三酯、低密度脂蛋白胆固醇、apoB升高以及HDL-C和apoAII降低有关。在此框架内，游离睾酮增加与apoB升高、HDL-C和apoAI降低有关，而雌二醇增加与HDL-C升高、甘油三酯、低密度脂蛋白胆固醇和apoB降低有关。
性类固醇激素的变化对脂质参数的变化有显著影响——游离睾酮水平升高具有致动脉粥样硬化作用，而雌二醇升高具有抗动脉粥样硬化作用。
