Cesur Salih
Refik Saydam Hifzissihha Merkezi, Tüberküloz Referans Laboratuvan, Ankara.
Mikrobiyol Bul. 2002 Jul-Oct;36(3-4):353-61.
Topical antibiotics offer a useful alternative to oral and parenteral agents in certain conditions and have some advantages such as easy to use, lower side effects, higher drug concentrations in the infected area, lower risk of developing bacterial resistance and being economical. The goals of topical antimicrobial therapy are to control microbial colonization, thus preventing development of invasive infections, prophylaxis and treatment of wound infections, pyodermas, burn infections and acne vulgaris, and eradication of Staphylococcus aureus nasal carriage. Topical antibiotics of choice include bacitracin, neomycin, polymyxin B, mupirocin, nitrofurazone and fusidic acid. In this review article, the characteristics and clinical uses of topical antimicrobials have been summarized.
在某些情况下，局部用抗生素为口服和胃肠外用药提供了一种有用的替代方法，并且具有一些优点，如使用方便、副作用较小、感染部位药物浓度较高、产生细菌耐药性的风险较低以及经济实惠。局部抗菌治疗的目标是控制微生物定植，从而预防侵袭性感染的发生、预防和治疗伤口感染、脓皮病、烧伤感染和寻常痤疮，以及根除金黄色葡萄球菌鼻腔定植。常用的局部用抗生素包括杆菌肽、新霉素、多粘菌素B、莫匹罗星、呋喃西林和夫西地酸。在这篇综述文章中，总结了局部用抗菌药物的特点和临床应用。
