Avakian A R, Brovkina I L, Lazarev A I
Patol Fiziol Eksp Ter. 2003 Apr-Jun(2):13-5.
Local cooling (LC) of the Wistar rat's foot to -120 degrees for 10 or 20 sec stimulates development of humoral immune response and delayed hypersensitivity induced by sheep erythrocytes. A stimulating action of short-term LC can be enhanced by introduction of retinol acetate into the cooling zone. The immunostimulating effect of short-term LC and retinal acetate is mediated by cytokines released by the cells of regional lymph nodes.
将Wistar大鼠的足部局部冷却至-120摄氏度，持续10或20秒，可刺激体液免疫反应的发展以及由绵羊红细胞诱导的迟发型超敏反应。通过将醋酸视黄醇引入冷却区域，可增强短期局部冷却的刺激作用。短期局部冷却和醋酸视黄醇的免疫刺激作用是由局部淋巴结细胞释放的细胞因子介导的。
