Brovkina I L, Konoplia A A, Uteshev B S, Rybnikov V N
Department of Sport Medicine, Kursk State Medical University, ul. K. Marksa 3, Kursk, 305033 Russia.
Eksp Klin Farmakol. 2004 Jan-Feb;67(1):32-6.
Hemorrhage and toxic lesions of hemopoietic tissues inhibit the development of various types of immune response and induce immunosuppressive properties in light erythrocytes, while not influencing the immunological activity of heavy erythrocytes. The immunomodulant action of pyridoxine, folate and cobalamin in various cases of anemia was observed for the joint (but not for separate) administration of two vitamin preparations; the most pronounced increase in the immune reactivity taking place upon the joint administration of cobalamin and folate.
造血组织的出血和毒性损伤会抑制各类免疫反应的发展，并在轻度红细胞中诱导免疫抑制特性，而对重度红细胞的免疫活性没有影响。在各种贫血病例中，观察到吡哆醇、叶酸和钴胺素的免疫调节作用是在联合（而非单独）给予两种维生素制剂时出现的；在联合给予钴胺素和叶酸时，免疫反应性的增加最为显著。
