发夹状核酶催化的RNA交叉连接与交换反应。
Cross-ligation and exchange reaction of RNA catalyzed by hairpin ribozymes.
作者信息
Komatsu Y, Koizumi M, Sekiguchi A, Ohtsuka E
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Nucleic Acids Symp Ser. 1992(27):43-4.
PMID:1283911
Abstract
The catalytic domain in the minus strand of the satellite RNA of tobacco ringspot virus (sTobRV(-)) assumes a hairpin-like secondary structure. This ribozyme catalyzes a cross-ligation reaction between substrate RNAs of different lengths. We constructed ribozymes to probe the activities of ligation and RNA fragment exchange.
摘要
烟草环斑病毒卫星RNA负链（sTobRV(-)）中的催化结构域呈现出类似发夹的二级结构。这种核酶催化不同长度底物RNA之间的交叉连接反应。我们构建了核酶以探究连接和RNA片段交换的活性。
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