Mori K, Asakura S, Morikawa N, Chaen T, Watanabe N, Mogi G, Takeyama M
Department of Clinical Pharmacy, Oita Medical University.
Arerugi. 1992 Dec;41(12):1651-7.
Substance P (SP) and vasoactive intestinal peptide (VIP) concentrations in nasal secretions and plasma from patients with nasal allergy to Japanese cedar pollen and healthy volunteers were measured from Jan to Dec, 1991 using EIA established by us. Simultaneously, the numbers of airborne pollens of Japanese cedar and cypress were counted, and the relation to the SP and VIP concentrations in nasal secretions from the patients with nasal allergy to Japanese cedar pollen was studied. The mean SP concentration in nasal secretions from the patients with nasal allergy to Japanese cedar pollen in the pollination season was 81.9 +/- 48.4 fmol/mg protein, which was significantly higher than that in the non-pollination season (30.4 +/- 14.7 fmol/mg protein) (p < 0.01). Likewise, the mean VIP concentration in nasal secretions from the patients with nasal allergy to Japanese cedar pollen in the pollination season was 14.2 +/- 10.4 fmol/ml protein, which was significantly higher than that in the non-pollination season (4.2 +/- 3.0 fmol/mg protein) (p < 0.01). The SP and VIP concentrations in nasal secretions from the healthy volunteers were not affected by the scattering of pollens. The SP and VIP concentrations in plasma from the patients and the healthy volunteers were not affected by the scattering of pollens.
1991年1月至12月期间，我们采用自行建立的酶免疫分析法（EIA），对日本雪松花粉过敏患者和健康志愿者鼻腔分泌物及血浆中的P物质（SP）和血管活性肠肽（VIP）浓度进行了测定。同时，统计了空气中日本雪松和柏树花粉的数量，并研究了其与日本雪松花粉过敏患者鼻腔分泌物中SP和VIP浓度的关系。在授粉季节，对日本雪松花粉过敏患者鼻腔分泌物中的SP平均浓度为81.9±48.4 fmol/mg蛋白质，显著高于非授粉季节（30.4±14.7 fmol/mg蛋白质）（p<0.01）。同样，在授粉季节，对日本雪松花粉过敏患者鼻腔分泌物中的VIP平均浓度为14.2±10.4 fmol/ml蛋白质，显著高于非授粉季节（4.2±3.0 fmol/mg蛋白质）（p<0.01）。健康志愿者鼻腔分泌物中的SP和VIP浓度不受花粉飘散的影响。患者和健康志愿者血浆中的SP和VIP浓度也不受花粉飘散的影响。
